Drug interactions
Chloramphenicol + Mirvetuximab soravtansine
Severity: Moderate
Chloramphenicol and Mirvetuximab soravtansine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The antibody-drug conjugate releases the cytotoxic payload DM4, which is cleared partly by CYP3A4. Chloramphenicol may raise DM4 exposure and increase toxicity such as ocular and hematologic adverse effects.
What this interaction means in plain words
Chloramphenicol and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Mirvetuximab soravtansine belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, which may reduce metabolism of the DM4 payload.
What to do
Monitor for adverse reactions, especially ocular toxicity, neuropathy and cytopenias. Consider an alternative antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Mirvetuximab soravtansine
Frequently asked questions
Can I take Chloramphenicol with Mirvetuximab soravtansine?
MediHelp rates the interaction as moderate. Chloramphenicol and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The antibody-drug conjugate releases the cytotoxic payload DM4, which is cleared partly by CYP3A4. Chloramphenicol may raise DM4 exposure and increase toxicity such as ocular and hematologic adverse effects.
How serious is the interaction between Chloramphenicol and Mirvetuximab soravtansine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions, especially ocular toxicity, neuropathy and cytopenias. Consider an alternative antibiotic if feasible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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