Drug interactions
Itraconazole + Mirvetuximab soravtansine
Severity: Moderate
Itraconazole and Mirvetuximab soravtansine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload DM4 is metabolized by CYP3A4, so a strong inhibitor such as itraconazole may increase exposure to it. This may heighten the risk of toxicities such as ocular, neurologic and hematologic effects.
What this interaction means in plain words
Itraconazole and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Mirvetuximab soravtansine belongs to Oncology.
Why it happens
CYP3A4 inhibition reduces clearance of the DM4 payload.
What to do
Monitor closely for adverse reactions, particularly ocular toxicity and neuropathy, or use an antifungal that does not inhibit CYP3A4 strongly where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Mirvetuximab soravtansine
Frequently asked questions
Can I take Itraconazole with Mirvetuximab soravtansine?
MediHelp rates the interaction as moderate. Itraconazole and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload DM4 is metabolized by CYP3A4, so a strong inhibitor such as itraconazole may increase exposure to it. This may heighten the risk of toxicities such as ocular, neurologic and hematologic effects.
How serious is the interaction between Itraconazole and Mirvetuximab soravtansine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions, particularly ocular toxicity and neuropathy, or use an antifungal that does not inhibit CYP3A4 strongly where feasible.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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