Drug interactions
Mifepristone + Mirvetuximab soravtansine
Severity: Moderate
Mifepristone and Mirvetuximab soravtansine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise exposure to DM4, the cytotoxic payload of mirvetuximab soravtansine. This may increase toxicities such as ocular and neuropathic effects.
What this interaction means in plain words
Mifepristone and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Mirvetuximab soravtansine belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of free DM4.
What to do
Monitor closely for adverse reactions including ocular toxicity and neuropathy. Consider an alternative to mifepristone if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Mirvetuximab soravtansine
Frequently asked questions
Can I take Mifepristone with Mirvetuximab soravtansine?
MediHelp rates the interaction as moderate. Mifepristone and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise exposure to DM4, the cytotoxic payload of mirvetuximab soravtansine. This may increase toxicities such as ocular and neuropathic effects.
How serious is the interaction between Mifepristone and Mirvetuximab soravtansine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions including ocular toxicity and neuropathy. Consider an alternative to mifepristone if feasible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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