Drug interactions
Mirvetuximab soravtansine + Posaconazole
Severity: Moderate
Mirvetuximab soravtansine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase exposure to DM4, the cytotoxic payload of mirvetuximab soravtansine, which may worsen ocular toxicity, neuropathy and other adverse reactions.
What this interaction means in plain words
Mirvetuximab soravtansine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirvetuximab soravtansine belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, which metabolizes unconjugated DM4.
What to do
Monitor closely for ocular and neurologic adverse reactions. Consider an alternative antifungal where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Mirvetuximab soravtansine
Frequently asked questions
Can I take Mirvetuximab soravtansine with Posaconazole?
MediHelp rates the interaction as moderate. Mirvetuximab soravtansine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase exposure to DM4, the cytotoxic payload of mirvetuximab soravtansine, which may worsen ocular toxicity, neuropathy and other adverse reactions.
How serious is the interaction between Mirvetuximab soravtansine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for ocular and neurologic adverse reactions. Consider an alternative antifungal where feasible.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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