Drug interactions
Mirvetuximab soravtansine + Voriconazole
Severity: Moderate
Mirvetuximab soravtansine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inhibitors may increase exposure to the cytotoxic payload DM4 released from mirvetuximab. This can increase toxicities such as ocular, hematologic and hepatic adverse effects.
What this interaction means in plain words
Mirvetuximab soravtansine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirvetuximab soravtansine belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of unconjugated DM4.
What to do
Monitor closely for adverse reactions, especially ocular toxicity and neutropenia. Consider a non-CYP3A-inhibiting antifungal if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Mirvetuximab soravtansine
Frequently asked questions
Can I take Mirvetuximab soravtansine with Voriconazole?
MediHelp rates the interaction as moderate. Mirvetuximab soravtansine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A inhibitors may increase exposure to the cytotoxic payload DM4 released from mirvetuximab. This can increase toxicities such as ocular, hematologic and hepatic adverse effects.
How serious is the interaction between Mirvetuximab soravtansine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions, especially ocular toxicity and neutropenia. Consider a non-CYP3A-inhibiting antifungal if feasible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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