Drug interactions
Clarithromycin + Mirvetuximab soravtansine
Severity: Moderate
Clarithromycin and Mirvetuximab soravtansine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirvetuximab releases the cytotoxic payload DM4, which is metabolized by CYP3A4. Clarithromycin may raise DM4 exposure and increase toxicities such as ocular and hematologic effects.
What this interaction means in plain words
Clarithromycin and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Mirvetuximab soravtansine belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by clarithromycin reduces clearance of the DM4 payload.
What to do
Monitor closely for adverse reactions such as ocular toxicity and neutropenia. Consider an alternative antibiotic that does not inhibit CYP3A4 where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Mirvetuximab soravtansine
Frequently asked questions
Can I take Clarithromycin with Mirvetuximab soravtansine?
MediHelp rates the interaction as moderate. Clarithromycin and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirvetuximab releases the cytotoxic payload DM4, which is metabolized by CYP3A4. Clarithromycin may raise DM4 exposure and increase toxicities such as ocular and hematologic effects.
How serious is the interaction between Clarithromycin and Mirvetuximab soravtansine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions such as ocular toxicity and neutropenia. Consider an alternative antibiotic that does not inhibit CYP3A4 where feasible.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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