Drug interactions
Labetalol + Metolazone
Severity: Minor
Labetalol and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol and metolazone have additive blood pressure lowering, which can be useful but may cause hypotension. Thiazide-related hypokalemia and hyperglycemia may occur, and beta-blockade can mask hypoglycemia symptoms.
What this interaction means in plain words
Labetalol and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Labetalol belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects; thiazide-induced metabolic changes may be relevant.
What to do
Monitor blood pressure, heart rate and serum potassium, and review glycemic control in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Metolazone?
MediHelp rates the interaction as minor. Labetalol and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labetalol and metolazone have additive blood pressure lowering, which can be useful but may cause hypotension. Thiazide-related hypokalemia and hyperglycemia may occur, and beta-blockade can mask hypoglycemia symptoms.
How serious is the interaction between Labetalol and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium, and review glycemic control in diabetic patients.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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