Drug interactions
Labetalol + Sevoflurane
Severity: Moderate
Labetalol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane cause dose-dependent vasodilation and myocardial depression. In patients on labetalol, hypotension and bradycardia can be exaggerated and the reflex tachycardia response is blunted.
What this interaction means in plain words
Labetalol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive vasodilation and cardiac depression combined with beta- and alpha-adrenergic blockade.
What to do
Tell the anesthesia team about beta-blocker use and monitor blood pressure and heart rate closely, lowering anesthetic concentration as needed. Treat hypotension with fluids or vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Labetalol with Sevoflurane?
MediHelp rates the interaction as moderate. Labetalol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane cause dose-dependent vasodilation and myocardial depression. In patients on labetalol, hypotension and bradycardia can be exaggerated and the reflex tachycardia response is blunted.
How serious is the interaction between Labetalol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about beta-blocker use and monitor blood pressure and heart rate closely, lowering anesthetic concentration as needed. Treat hypotension with fluids or vasopressors.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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