Drug interactions
Labetalol + Tiotropium-olodaterol
Severity: Major
Labetalol and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta receptors and can oppose the bronchodilating effect of olodaterol while also provoking bronchospasm in patients with COPD or asthma. The result can be reduced bronchodilator efficacy and worsening airflow obstruction.
What this interaction means in plain words
Labetalol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Labetalol belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta2 receptors by a non-selective beta-blocker with alpha-blocking activity.
What to do
Avoid labetalol in patients needing olodaterol where possible and choose a cardioselective beta-blocker or non-beta-blocker alternative. If a beta-blocker is essential, monitor respiratory function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Labetalol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks beta receptors and can oppose the bronchodilating effect of olodaterol while also provoking bronchospasm in patients with COPD or asthma. The result can be reduced bronchodilator efficacy and worsening airflow obstruction.
How serious is the interaction between Labetalol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid labetalol in patients needing olodaterol where possible and choose a cardioselective beta-blocker or non-beta-blocker alternative. If a beta-blocker is essential, monitor respiratory function closely.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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