Drug interactions
Lacosamide + Piroxicam
Severity: Minor
Lacosamide and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lacosamide is partly metabolized by CYP2C9, CYP2C19 and CYP3A4, and piroxicam is a CYP2C9 substrate rather than a meaningful inhibitor. Any effect on lacosamide exposure is not expected to be clinically important.
What this interaction means in plain words
Lacosamide and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Piroxicam belongs to Musculoskeletal.
Why it happens
No established mechanism; piroxicam is not a recognized clinically relevant CYP2C9 inhibitor.
What to do
No dose adjustment is needed. Monitor for usual lacosamide adverse effects such as dizziness or PR interval changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Piroxicam?
MediHelp rates the interaction as minor. Lacosamide and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lacosamide is partly metabolized by CYP2C9, CYP2C19 and CYP3A4, and piroxicam is a CYP2C9 substrate rather than a meaningful inhibitor. Any effect on lacosamide exposure is not expected to be clinically important.
How serious is the interaction between Lacosamide and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for usual lacosamide adverse effects such as dizziness or PR interval changes.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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