Drug interactions
Lacosamide + Ribociclib
Severity: Minor
Lacosamide and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor, and CYP3A4 is only one of several pathways involved in lacosamide clearance. Any rise in lacosamide exposure is expected to be small. Dose-related dizziness, PR interval prolongation and sedation could be slightly more likely.
What this interaction means in plain words
Lacosamide and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib weakly inhibits CYP3A4, one of the minor metabolic routes of lacosamide (alongside CYP2C9 and CYP2C19).
What to do
No dose change is normally needed. Watch for dizziness, ataxia and conduction effects, and consider an ECG if the patient has pre-existing cardiac conduction disease, since ribociclib also prolongs the QT interval.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Lacosamide with Ribociclib?
MediHelp rates the interaction as minor. Lacosamide and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate CYP3A4 inhibitor, and CYP3A4 is only one of several pathways involved in lacosamide clearance. Any rise in lacosamide exposure is expected to be small. Dose-related dizziness, PR interval prolongation and sedation could be slightly more likely.
How serious is the interaction between Lacosamide and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Watch for dizziness, ataxia and conduction effects, and consider an ECG if the patient has pre-existing cardiac conduction disease, since ribociclib also prolongs the QT interval.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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