Drug interactions
Lacosamide + Voriconazole
Severity: Minor
Lacosamide and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, CYP2C9 and CYP2C19, which contribute to lacosamide metabolism, so lacosamide levels may rise modestly. Lacosamide is also eliminated renally and CYP2C19 is the main route, so the effect is usually small but may increase dizziness and PR interval prolongation.
What this interaction means in plain words
Lacosamide and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP enzymes involved in lacosamide metabolism, slightly reducing clearance.
What to do
No routine dose change; monitor for dizziness, ataxia and conduction abnormalities, and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Voriconazole?
MediHelp rates the interaction as minor. Lacosamide and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP3A4, CYP2C9 and CYP2C19, which contribute to lacosamide metabolism, so lacosamide levels may rise modestly. Lacosamide is also eliminated renally and CYP2C19 is the main route, so the effect is usually small but may increase dizziness and PR interval prolongation.
How serious is the interaction between Lacosamide and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for dizziness, ataxia and conduction abnormalities, and reduce the dose if they occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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