Drug interactions
Lanthanum carbonate + Levofloxacin
Severity: Moderate
Lanthanum carbonate and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanthanum is a polyvalent cation that binds oral levofloxacin in the gut and reduces its absorption. This can lower antibiotic exposure and risk treatment failure.
What this interaction means in plain words
Lanthanum carbonate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lanthanum carbonate belongs to Miscellaneous; Levofloxacin belongs to Anti Bacterial.
Why it happens
Chelation of levofloxacin by lanthanum cations in the gastrointestinal tract, reducing absorption.
What to do
Give oral levofloxacin at least 2 hours before or 2 hours after lanthanum carbonate. Intravenous levofloxacin is not affected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Lanthanum carbonate
Frequently asked questions
Can I take Lanthanum carbonate with Levofloxacin?
MediHelp rates the interaction as moderate. Lanthanum carbonate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanthanum is a polyvalent cation that binds oral levofloxacin in the gut and reduces its absorption. This can lower antibiotic exposure and risk treatment failure.
How serious is the interaction between Lanthanum carbonate and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral levofloxacin at least 2 hours before or 2 hours after lanthanum carbonate. Intravenous levofloxacin is not affected.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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