Drug interactions
Lapatinib + Leuprolide
Severity: Moderate
Lapatinib and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and androgen deprivation with leuprolide may contribute as well. The combination could increase the risk of QT-related arrhythmia.
What this interaction means in plain words
Lapatinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation from lapatinib's direct effect on cardiac repolarization and androgen deprivation from leuprolide.
What to do
Perform a baseline ECG and periodic follow-up ECGs, and correct hypokalemia and hypomagnesemia. Stop or reduce lapatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Leuprolide?
MediHelp rates the interaction as moderate. Lapatinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval, and androgen deprivation with leuprolide may contribute as well. The combination could increase the risk of QT-related arrhythmia.
How serious is the interaction between Lapatinib and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and periodic follow-up ECGs, and correct hypokalemia and hypomagnesemia. Stop or reduce lapatinib if QTc becomes markedly prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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