Drug interactions
Lapatinib + Talazoparib
Severity: Moderate
Lapatinib and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits BCRP and P-gp and may raise talazoparib exposure. This could worsen myelosuppression.
What this interaction means in plain words
Lapatinib and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Talazoparib belongs to Oncology.
Why it happens
Inhibition of BCRP and P-gp efflux of talazoparib.
What to do
Monitor blood counts closely. Reduce the talazoparib dose per labeling if the combination cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Lapatinib with Talazoparib?
MediHelp rates the interaction as moderate. Lapatinib and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits BCRP and P-gp and may raise talazoparib exposure. This could worsen myelosuppression.
How serious is the interaction between Lapatinib and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely. Reduce the talazoparib dose per labeling if the combination cannot be avoided.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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