Drug interactions
Lapatinib + Teriflunomide
Severity: Moderate
Lapatinib and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is metabolized mainly by CYP3A4 with a minor CYP2C8 contribution, so CYP2C8 inhibition by teriflunomide may have a small effect. Both agents can cause hepatotoxicity.
What this interaction means in plain words
Lapatinib and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide inhibits CYP2C8, a minor pathway for lapatinib, and both drugs have additive hepatotoxic potential.
What to do
Monitor liver function tests periodically and watch for lapatinib toxicity such as diarrhea or QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Teriflunomide?
MediHelp rates the interaction as moderate. Lapatinib and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is metabolized mainly by CYP3A4 with a minor CYP2C8 contribution, so CYP2C8 inhibition by teriflunomide may have a small effect. Both agents can cause hepatotoxicity.
How serious is the interaction between Lapatinib and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests periodically and watch for lapatinib toxicity such as diarrhea or QT effects.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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