Drug interactions
Lasmiditan + Linagliptin
Severity: Minor
Lasmiditan and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-gp and may raise linagliptin absorption. Linagliptin is a P-gp substrate, but the expected change is small and use of lasmiditan is intermittent.
What this interaction means in plain words
Lasmiditan and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Linagliptin belongs to Endocrine.
Why it happens
P-gp inhibition by lasmiditan reduces linagliptin efflux.
What to do
No dose change is needed. Be aware of the interaction and monitor glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Linagliptin?
MediHelp rates the interaction as minor. Lasmiditan and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits intestinal P-gp and may raise linagliptin absorption. Linagliptin is a P-gp substrate, but the expected change is small and use of lasmiditan is intermittent.
How serious is the interaction between Lasmiditan and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Be aware of the interaction and monitor glucose.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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