Drug interactions
Lasmiditan + Ranolazine
Severity: Moderate
Lasmiditan and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein and may increase absorption and exposure of ranolazine, a P-gp substrate. Higher ranolazine levels could increase dose-related adverse effects including QT prolongation.
What this interaction means in plain words
Lasmiditan and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux by lasmiditan, increasing ranolazine bioavailability.
What to do
Avoid concurrent use on the same day if possible; otherwise monitor for ranolazine adverse effects and consider lowering the ranolazine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Ranolazine?
MediHelp rates the interaction as moderate. Lasmiditan and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits intestinal P-glycoprotein and may increase absorption and exposure of ranolazine, a P-gp substrate. Higher ranolazine levels could increase dose-related adverse effects including QT prolongation.
How serious is the interaction between Lasmiditan and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use on the same day if possible; otherwise monitor for ranolazine adverse effects and consider lowering the ranolazine dose.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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