Drug interactions
Lasmiditan + Risperidone
Severity: Minor
Lasmiditan and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro, which may modestly increase risperidone exposure. Clinical significance is uncertain and effects would mainly be dose-related adverse effects.
What this interaction means in plain words
Lasmiditan and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Lasmiditan may inhibit intestinal P-glycoprotein, increasing risperidone absorption.
What to do
No routine adjustment is needed. Be alert for increased sedation or extrapyramidal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Risperidone?
MediHelp rates the interaction as minor. Lasmiditan and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro, which may modestly increase risperidone exposure. Clinical significance is uncertain and effects would mainly be dose-related adverse effects.
How serious is the interaction between Lasmiditan and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be alert for increased sedation or extrapyramidal symptoms.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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