Drug interactions
Lasmiditan + Sevoflurane
Severity: Moderate
Lasmiditan and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence and has not been studied with other CNS depressants. Combined with sevoflurane, sedation and psychomotor impairment may be greater or last longer.
What this interaction means in plain words
Lasmiditan and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; the interaction is predicted rather than studied.
What to do
Avoid giving lasmiditan around the time of anesthesia and monitor sedation during recovery. Advise patients not to drive for at least 8 hours after a lasmiditan dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Sevoflurane?
MediHelp rates the interaction as moderate. Lasmiditan and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence and has not been studied with other CNS depressants. Combined with sevoflurane, sedation and psychomotor impairment may be greater or last longer.
How serious is the interaction between Lasmiditan and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving lasmiditan around the time of anesthesia and monitor sedation during recovery. Advise patients not to drive for at least 8 hours after a lasmiditan dose.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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