Drug interactions
Lasmiditan + Trimipramine
Severity: Moderate
Lasmiditan and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan causes sedation and dizziness, which may be additive with the sedating effects of trimipramine. Because trimipramine affects serotonin reuptake, serotonin syndrome is a theoretical concern, although lasmiditan acts at 5-HT1F receptors.
What this interaction means in plain words
Lasmiditan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with a theoretical serotonergic contribution.
What to do
Counsel patients to avoid driving for at least 8 hours after lasmiditan and monitor for excess sedation. Watch for signs of serotonin toxicity such as agitation, tremor and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Trimipramine?
MediHelp rates the interaction as moderate. Lasmiditan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan causes sedation and dizziness, which may be additive with the sedating effects of trimipramine. Because trimipramine affects serotonin reuptake, serotonin syndrome is a theoretical concern, although lasmiditan acts at 5-HT1F receptors.
How serious is the interaction between Lasmiditan and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving for at least 8 hours after lasmiditan and monitor for excess sedation. Watch for signs of serotonin toxicity such as agitation, tremor and hyperthermia.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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