Drug interactions
Lasmiditan + Vigabatrin
Severity: Moderate
Lasmiditan and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan can cause sedation, dizziness and cognitive effects, and its use with other CNS depressants has not been well studied. Vigabatrin also causes somnolence, so additive impairment is plausible.
What this interaction means in plain words
Lasmiditan and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects via pharmacodynamic synergism.
What to do
Advise the patient not to drive or operate machinery for at least 8 hours after each lasmiditan dose. Monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Vigabatrin?
MediHelp rates the interaction as moderate. Lasmiditan and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan can cause sedation, dizziness and cognitive effects, and its use with other CNS depressants has not been well studied. Vigabatrin also causes somnolence, so additive impairment is plausible.
How serious is the interaction between Lasmiditan and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient not to drive or operate machinery for at least 8 hours after each lasmiditan dose. Monitor for excess sedation.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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