Drug interactions
Lasmiditan + Vortioxetine
Severity: Moderate
Lasmiditan and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan causes dizziness and sedation, and it is a 5-HT1F agonist. Combining it with vortioxetine may add to CNS effects, and serotonergic overlap is theoretically possible, though serotonin syndrome has not been well established.
What this interaction means in plain words
Lasmiditan and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, with a theoretical serotonergic contribution.
What to do
Counsel patients to avoid driving for at least 8 hours after a lasmiditan dose. Monitor for excessive sedation and for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Vortioxetine?
MediHelp rates the interaction as moderate. Lasmiditan and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan causes dizziness and sedation, and it is a 5-HT1F agonist. Combining it with vortioxetine may add to CNS effects, and serotonergic overlap is theoretically possible, though serotonin syndrome has not been well established.
How serious is the interaction between Lasmiditan and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving for at least 8 hours after a lasmiditan dose. Monitor for excessive sedation and for signs of serotonin toxicity.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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