Drug interactions
Leflunomide + Leniolisib
Severity: Moderate
Leflunomide and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, which can raise exposure to BCRP substrates such as teriflunomide, the active metabolite of leflunomide. This may increase the risk of leflunomide toxicity including hepatotoxicity and cytopenias.
What this interaction means in plain words
Leflunomide and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibition of BCRP reduces efflux of teriflunomide, raising its exposure.
What to do
Monitor liver enzymes and blood counts closely, and consider reducing the leflunomide dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leflunomide with Leniolisib?
MediHelp rates the interaction as moderate. Leflunomide and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, which can raise exposure to BCRP substrates such as teriflunomide, the active metabolite of leflunomide. This may increase the risk of leflunomide toxicity including hepatotoxicity and cytopenias.
How serious is the interaction between Leflunomide and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood counts closely, and consider reducing the leflunomide dose if adverse effects occur.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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