Drug interactions
Leflunomide + Regorafenib
Severity: Moderate
Leflunomide and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and raise exposure to teriflunomide, the active metabolite of leflunomide, which is a BCRP substrate. Higher levels could increase hepatotoxicity and myelosuppression.
What this interaction means in plain words
Leflunomide and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Regorafenib belongs to Oncology.
Why it happens
Regorafenib inhibits BCRP (ABCG2) transport, decreasing efflux of teriflunomide.
What to do
Monitor liver enzymes and blood counts during coadministration. Reduce the leflunomide dose or consider alternatives if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Regorafenib
Frequently asked questions
Can I take Leflunomide with Regorafenib?
MediHelp rates the interaction as moderate. Leflunomide and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and raise exposure to teriflunomide, the active metabolite of leflunomide, which is a BCRP substrate. Higher levels could increase hepatotoxicity and myelosuppression.
How serious is the interaction between Leflunomide and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood counts during coadministration. Reduce the leflunomide dose or consider alternatives if toxicity appears.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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