Drug interactions
Lemborexant + Lomustine
Severity: Minor
Lemborexant and Lomustine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a CYP3A4 substrate whose exposure rises with CYP3A4 inhibitors, increasing somnolence and next-day impairment. Lomustine is not an established CYP3A4 inhibitor, so any effect is theoretical.
What this interaction means in plain words
Lemborexant and Lomustine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lemborexant belongs to Central Nervous System; Lomustine belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by lomustine, which is not well established.
What to do
No routine dose change; monitor for excessive sedation and next-day drowsiness, and reduce the lemborexant dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Lomustine?
MediHelp rates the interaction as minor. Lemborexant and Lomustine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lemborexant is a CYP3A4 substrate whose exposure rises with CYP3A4 inhibitors, increasing somnolence and next-day impairment. Lomustine is not an established CYP3A4 inhibitor, so any effect is theoretical.
How serious is the interaction between Lemborexant and Lomustine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for excessive sedation and next-day drowsiness, and reduce the lemborexant dose if these occur.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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