Drug interactions
Lemborexant + Posaconazole
Severity: Major
Lemborexant and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole markedly increases lemborexant exposure because lemborexant is cleared by CYP3A4. This can cause excessive somnolence, next-day impairment and impaired driving ability.
What this interaction means in plain words
Lemborexant and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lemborexant belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces lemborexant clearance.
What to do
Avoid the combination per labeling and select a different hypnotic or antifungal. If lemborexant must continue, use the lowest dose and counsel about next-day sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Posaconazole?
MediHelp rates the interaction as major. Lemborexant and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole markedly increases lemborexant exposure because lemborexant is cleared by CYP3A4. This can cause excessive somnolence, next-day impairment and impaired driving ability.
How serious is the interaction between Lemborexant and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination per labeling and select a different hypnotic or antifungal. If lemborexant must continue, use the lowest dose and counsel about next-day sedation.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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