Drug interactions
Lemborexant + Prochlorperazine
Severity: Moderate
Lemborexant and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining lemborexant with another sedating agent such as prochlorperazine can increase drowsiness and psychomotor impairment. Next-morning effects and fall risk may be greater, especially in older patients.
What this interaction means in plain words
Lemborexant and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of orexin receptor antagonism and phenothiazine sedation.
What to do
Start with the lowest lemborexant dose and reduce it if sedation occurs. Warn patients about next-day impairment and avoid combining with other sedatives or alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Prochlorperazine?
MediHelp rates the interaction as moderate. Lemborexant and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining lemborexant with another sedating agent such as prochlorperazine can increase drowsiness and psychomotor impairment. Next-morning effects and fall risk may be greater, especially in older patients.
How serious is the interaction between Lemborexant and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest lemborexant dose and reduce it if sedation occurs. Warn patients about next-day impairment and avoid combining with other sedatives or alcohol.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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