Drug interactions
Lemborexant + Propofol
Severity: Moderate
Lemborexant and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a sedative-hypnotic and may add to the CNS depressant effects of propofol. Pharmacokinetic effects are unlikely to be meaningful given propofol's multiple clearance pathways.
What this interaction means in plain words
Lemborexant and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Titrate propofol to effect and monitor sedation depth and respiration. Tell the anesthesia team about recent lemborexant use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Propofol?
MediHelp rates the interaction as moderate. Lemborexant and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is a sedative-hypnotic and may add to the CNS depressant effects of propofol. Pharmacokinetic effects are unlikely to be meaningful given propofol's multiple clearance pathways.
How serious is the interaction between Lemborexant and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor sedation depth and respiration. Tell the anesthesia team about recent lemborexant use.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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