Drug interactions
Lemborexant + Vilazodone
Severity: Moderate
Lemborexant and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is an orexin receptor antagonist that causes somnolence and next-day impairment. Vilazodone may add to drowsiness, so psychomotor impairment can be more pronounced than with either drug alone.
What this interaction means in plain words
Lemborexant and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; the interaction is pharmacodynamic.
What to do
Monitor for next-day sedation and impaired alertness, and reduce the lemborexant dose if daytime impairment occurs. Counsel patients about driving and similar activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Vilazodone?
MediHelp rates the interaction as moderate. Lemborexant and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is an orexin receptor antagonist that causes somnolence and next-day impairment. Vilazodone may add to drowsiness, so psychomotor impairment can be more pronounced than with either drug alone.
How serious is the interaction between Lemborexant and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for next-day sedation and impaired alertness, and reduce the lemborexant dose if daytime impairment occurs. Counsel patients about driving and similar activities.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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