Drug interactions
Lenacapavir + Medroxyprogesterone
Severity: Minor
Lenacapavir and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a very long half-life, so it may raise medroxyprogesterone exposure for months after the last dose. The clinical significance is uncertain and probably modest.
What this interaction means in plain words
Lenacapavir and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Medroxyprogesterone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of medroxyprogesterone by lenacapavir.
What to do
No dose change is usually needed; monitor for progestogenic adverse effects during and for several months after lenacapavir therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Medroxyprogesterone?
MediHelp rates the interaction as minor. Lenacapavir and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor with a very long half-life, so it may raise medroxyprogesterone exposure for months after the last dose. The clinical significance is uncertain and probably modest.
How serious is the interaction between Lenacapavir and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for progestogenic adverse effects during and for several months after lenacapavir therapy.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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