Drug interactions
Lenacapavir + Montelukast
Severity: Minor
Lenacapavir and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor, and this effect can persist for months after the last subcutaneous dose. Montelukast exposure may rise modestly, although its wide safety margin makes serious toxicity unlikely.
What this interaction means in plain words
Lenacapavir and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Montelukast belongs to Respiratory.
Why it happens
Lenacapavir inhibits CYP3A4, which contributes to montelukast metabolism alongside CYP2C8 and CYP2C9.
What to do
No dose change is usually needed; watch for headache, abdominal pain or neuropsychiatric effects of montelukast, including in the months after the last lenacapavir injection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Montelukast?
MediHelp rates the interaction as minor. Lenacapavir and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A4 inhibitor, and this effect can persist for months after the last subcutaneous dose. Montelukast exposure may rise modestly, although its wide safety margin makes serious toxicity unlikely.
How serious is the interaction between Lenacapavir and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for headache, abdominal pain or neuropsychiatric effects of montelukast, including in the months after the last lenacapavir injection.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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