Drug interactions
Lenacapavir + Vilazodone
Severity: Moderate
Lenacapavir and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise vilazodone concentrations. This may increase dose-related adverse effects such as nausea, diarrhea and serotonergic symptoms.
What this interaction means in plain words
Lenacapavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Vilazodone belongs to Central Nervous System.
Why it happens
Lenacapavir inhibition of CYP3A4 metabolism of vilazodone.
What to do
Monitor for vilazodone adverse effects and reduce the dose if intolerance develops. The inhibitory effect may persist for months after the last subcutaneous lenacapavir dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Vilazodone?
MediHelp rates the interaction as moderate. Lenacapavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise vilazodone concentrations. This may increase dose-related adverse effects such as nausea, diarrhea and serotonergic symptoms.
How serious is the interaction between Lenacapavir and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vilazodone adverse effects and reduce the dose if intolerance develops. The inhibitory effect may persist for months after the last subcutaneous lenacapavir dose.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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