Drug interactions
Leniolisib + Riluzole
Severity: Moderate
Leniolisib and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak CYP1A2 inhibitor in the labeling and may increase exposure to CYP1A2 substrates. Riluzole is metabolised mainly by CYP1A2, so levels and dose-related toxicity such as hepatotoxicity may rise.
What this interaction means in plain words
Leniolisib and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Riluzole belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2-mediated metabolism of riluzole.
What to do
Monitor for riluzole adverse effects and liver enzymes. Reduce the riluzole dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Riluzole?
MediHelp rates the interaction as moderate. Leniolisib and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is a weak CYP1A2 inhibitor in the labeling and may increase exposure to CYP1A2 substrates. Riluzole is metabolised mainly by CYP1A2, so levels and dose-related toxicity such as hepatotoxicity may rise.
How serious is the interaction between Leniolisib and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for riluzole adverse effects and liver enzymes. Reduce the riluzole dose if toxicity occurs.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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