Drug interactions
Lenvatinib + Moxifloxacin
Severity: Moderate
Lenvatinib and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and lenvatinib labelling advises ECG monitoring with other QT-prolonging drugs. Combined use increases the risk of torsades de pointes, and lenvatinib-associated electrolyte disturbances can add to this.
What this interaction means in plain words
Lenvatinib and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarisation.
What to do
Monitor ECG and electrolytes, correcting hypokalemia, hypomagnesemia and hypocalcemia. Consider a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Moxifloxacin?
MediHelp rates the interaction as moderate. Lenvatinib and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs prolong the QT interval, and lenvatinib labelling advises ECG monitoring with other QT-prolonging drugs. Combined use increases the risk of torsades de pointes, and lenvatinib-associated electrolyte disturbances can add to this.
How serious is the interaction between Lenvatinib and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting hypokalemia, hypomagnesemia and hypocalcemia. Consider a non-QT-prolonging antibiotic.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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