Drug interactions
Lenvatinib + Solifenacin
Severity: Moderate
Lenvatinib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval, and solifenacin has a dose-related QT effect. Combined use may increase the chance of arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Lenvatinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and correct potassium, magnesium and calcium abnormalities. Consider an alternative bladder agent if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Solifenacin?
MediHelp rates the interaction as moderate. Lenvatinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval, and solifenacin has a dose-related QT effect. Combined use may increase the chance of arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Lenvatinib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium, magnesium and calcium abnormalities. Consider an alternative bladder agent if QTc lengthens.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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