Drug interactions
Leriglitazone + Rifampicin
Severity: Moderate
Leriglitazone and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin strongly induces CYP2C8 and CYP3A, which is expected to reduce leriglitazone exposure considerably, as seen with other glitazones.
What this interaction means in plain words
Leriglitazone and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leriglitazone belongs to Central Nervous System; Rifampicin belongs to Anti Bacterial.
Why it happens
Induction of CYP2C8 and CYP3A4 increases leriglitazone clearance.
What to do
Avoid if possible. If rifampicin is necessary, monitor clinical response and glycaemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Leriglitazone and Rifampicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Leriglitazone with Rifampicin?
MediHelp rates the interaction as moderate. Leriglitazone and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin strongly induces CYP2C8 and CYP3A, which is expected to reduce leriglitazone exposure considerably, as seen with other glitazones.
How serious is the interaction between Leriglitazone and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If rifampicin is necessary, monitor clinical response and glycaemia.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Clarithromycin. The full list is on the Leriglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
