Drug interactions
Leriglitazone + Verapamil
Severity: Moderate
Leriglitazone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A inhibitor that may modestly raise leriglitazone levels. The clinical effect is likely small but could add to fluid retention.
What this interaction means in plain words
Leriglitazone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leriglitazone belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 modestly reduces leriglitazone metabolism.
What to do
Consider an alternative antihypertensive such as an ACE inhibitor. If continued, monitor for oedema and weight gain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Leriglitazone with Verapamil?
MediHelp rates the interaction as moderate. Leriglitazone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A inhibitor that may modestly raise leriglitazone levels. The clinical effect is likely small but could add to fluid retention.
How serious is the interaction between Leriglitazone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antihypertensive such as an ACE inhibitor. If continued, monitor for oedema and weight gain.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Clarithromycin. The full list is on the Leriglitazone page.
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