Drug interactions
Lesinurad + Nitisinone
Severity: Moderate
Lesinurad and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, the main enzyme metabolizing lesinurad, and may raise lesinurad levels. Higher exposure could increase renal adverse effects such as elevated creatinine and kidney injury.
What this interaction means in plain words
Lesinurad and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lesinurad belongs to Genitourinary; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9-mediated metabolism of lesinurad.
What to do
Monitor renal function and serum creatinine closely; avoid the combination in patients with reduced kidney function, and reassess uric acid therapy if creatinine rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Lesinurad with Nitisinone?
MediHelp rates the interaction as moderate. Lesinurad and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone inhibits CYP2C9, the main enzyme metabolizing lesinurad, and may raise lesinurad levels. Higher exposure could increase renal adverse effects such as elevated creatinine and kidney injury.
How serious is the interaction between Lesinurad and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum creatinine closely; avoid the combination in patients with reduced kidney function, and reassess uric acid therapy if creatinine rises.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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