Drug interactions
Lesinurad + Pacritinib
Severity: Moderate
Lesinurad and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad may lower pacritinib exposure because pacritinib is cleared mainly by CYP3A4. Reduced exposure could lessen control of myelofibrosis-related splenomegaly and symptoms.
What this interaction means in plain words
Lesinurad and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lesinurad belongs to Genitourinary; Pacritinib belongs to Oncology.
Why it happens
Lesinurad is a weak CYP3A4 inducer that can increase pacritinib metabolism.
What to do
Monitor spleen size and symptom response to pacritinib if lesinurad is used, and consider an alternative urate-lowering agent if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Lesinurad with Pacritinib?
MediHelp rates the interaction as moderate. Lesinurad and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad may lower pacritinib exposure because pacritinib is cleared mainly by CYP3A4. Reduced exposure could lessen control of myelofibrosis-related splenomegaly and symptoms.
How serious is the interaction between Lesinurad and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen size and symptom response to pacritinib if lesinurad is used, and consider an alternative urate-lowering agent if efficacy declines.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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