Drug interactions
Lesinurad + Ubrogepant
Severity: Minor
Lesinurad and Ubrogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak CYP3A inducer and may lower ubrogepant exposure. This could reduce migraine relief.
What this interaction means in plain words
Lesinurad and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lesinurad belongs to Genitourinary; Ubrogepant belongs to Central Nervous System.
Why it happens
Lesinurad induces intestinal and hepatic CYP3A4, increasing ubrogepant metabolism.
What to do
Consider the higher ubrogepant dose recommended in labeling for weak or moderate CYP3A inducers. Reassess migraine response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Lesinurad with Ubrogepant?
MediHelp rates the interaction as minor. Lesinurad and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is a weak CYP3A inducer and may lower ubrogepant exposure. This could reduce migraine relief.
How serious is the interaction between Lesinurad and Ubrogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider the higher ubrogepant dose recommended in labeling for weak or moderate CYP3A inducers. Reassess migraine response.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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