Drug interactions
Letermovir + Mirtazapine
Severity: Minor
Letermovir and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise concentrations of CYP3A substrates. Mirtazapine exposure could increase somewhat, but the effect is expected to be modest given its multiple metabolic pathways.
What this interaction means in plain words
Letermovir and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Mirtazapine belongs to Central Nervous System.
Why it happens
Letermovir inhibits CYP3A4, reducing mirtazapine clearance.
What to do
Watch for increased sedation or adverse effects during letermovir therapy and lower the mirtazapine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Mirtazapine?
MediHelp rates the interaction as minor. Letermovir and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir is a moderate CYP3A inhibitor and may raise concentrations of CYP3A substrates. Mirtazapine exposure could increase somewhat, but the effect is expected to be modest given its multiple metabolic pathways.
How serious is the interaction between Letermovir and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for increased sedation or adverse effects during letermovir therapy and lower the mirtazapine dose if needed.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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