Drug interactions
Letermovir + Modafinil
Severity: Minor
Letermovir and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise modafinil concentrations. Letermovir levels could be affected by modafinil induction of CYP3A, though this is less well characterized.
What this interaction means in plain words
Letermovir and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Modafinil belongs to Central Nervous System.
Why it happens
Letermovir inhibits CYP3A4, reducing modafinil clearance.
What to do
Monitor for modafinil adverse effects such as insomnia, headache, or anxiety, and reduce the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Modafinil?
MediHelp rates the interaction as minor. Letermovir and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir is a moderate CYP3A inhibitor and may raise modafinil concentrations. Letermovir levels could be affected by modafinil induction of CYP3A, though this is less well characterized.
How serious is the interaction between Letermovir and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects such as insomnia, headache, or anxiety, and reduce the dose if needed.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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