Drug interactions
Letermovir + Nevirapine
Severity: Moderate
Letermovir and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir can modestly alter CYP3A substrates. Nevirapine exposure could change, though letermovir also may induce CYP2B6 and CYP2C9/19, making net effect uncertain.
What this interaction means in plain words
Letermovir and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Nevirapine belongs to Anti Virals.
Why it happens
Letermovir moderately inhibits CYP3A and induces other enzymes, so the net effect on nevirapine is not well established.
What to do
Monitor nevirapine tolerability including liver tests and rash, and check virologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Nevirapine?
MediHelp rates the interaction as moderate. Letermovir and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir can modestly alter CYP3A substrates. Nevirapine exposure could change, though letermovir also may induce CYP2B6 and CYP2C9/19, making net effect uncertain.
How serious is the interaction between Letermovir and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor nevirapine tolerability including liver tests and rash, and check virologic response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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