Drug interactions
Letermovir + Risperidone
Severity: Minor
Letermovir and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and may modestly raise levels of risperidone's metabolites and parent drug. Adverse effects such as sedation, hypotension and extrapyramidal symptoms may become more likely.
What this interaction means in plain words
Letermovir and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Risperidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by letermovir, reducing risperidone metabolism.
What to do
Monitor for increased sedation, hypotension and extrapyramidal symptoms during letermovir therapy. Reduce the risperidone dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Risperidone?
MediHelp rates the interaction as minor. Letermovir and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits CYP3A4 and may modestly raise levels of risperidone's metabolites and parent drug. Adverse effects such as sedation, hypotension and extrapyramidal symptoms may become more likely.
How serious is the interaction between Letermovir and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, hypotension and extrapyramidal symptoms during letermovir therapy. Reduce the risperidone dose if they occur.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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