Drug interactions
Letermovir + Zileuton
Severity: Moderate
Letermovir and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A moderately and may raise concentrations of CYP3A substrates, and zileuton is partly metabolized by CYP3A4. Zileuton exposure could increase, with a greater risk of dose-related adverse effects, especially hepatotoxicity.
What this interaction means in plain words
Letermovir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Zileuton belongs to Respiratory.
Why it happens
Letermovir inhibits CYP3A4, reducing the metabolic clearance of zileuton.
What to do
Monitor ALT at baseline and periodically during combined use, and reduce or stop zileuton if liver enzymes rise or symptoms of hepatic injury appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Zileuton?
MediHelp rates the interaction as moderate. Letermovir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A moderately and may raise concentrations of CYP3A substrates, and zileuton is partly metabolized by CYP3A4. Zileuton exposure could increase, with a greater risk of dose-related adverse effects, especially hepatotoxicity.
How serious is the interaction between Letermovir and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT at baseline and periodically during combined use, and reduce or stop zileuton if liver enzymes rise or symptoms of hepatic injury appear.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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