Drug interactions
Leuprolide + Levofloxacin
Severity: Moderate
Leuprolide and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can lengthen the QT interval, and levofloxacin has similar effects. Combined use may increase the risk of torsades de pointes, especially in patients with other cardiac risk factors.
What this interaction means in plain words
Leuprolide and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation; androgen suppression alters cardiac repolarization while levofloxacin blocks hERG potassium channels.
What to do
Check baseline ECG and electrolytes and monitor QTc if the combination is needed. Prefer a non-QT-prolonging antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Levofloxacin?
MediHelp rates the interaction as moderate. Leuprolide and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can lengthen the QT interval, and levofloxacin has similar effects. Combined use may increase the risk of torsades de pointes, especially in patients with other cardiac risk factors.
How serious is the interaction between Leuprolide and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor QTc if the combination is needed. Prefer a non-QT-prolonging antibiotic when feasible.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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