Drug interactions
Leuprolide + Mifepristone
Severity: Major
Leuprolide and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide can prolong the QT interval, and mifepristone also prolongs QT. Using them together increases the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Leuprolide and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Leuprolide belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation from androgen deprivation and mifepristone's effect on cardiac repolarization.
What to do
Avoid the combination where possible. If both are needed, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Leuprolide with Mifepristone?
MediHelp rates the interaction as major. Leuprolide and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Androgen deprivation with leuprolide can prolong the QT interval, and mifepristone also prolongs QT. Using them together increases the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Leuprolide and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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