Drug interactions
Leuprolide + Propafenone
Severity: Moderate
Leuprolide and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide may prolong the QT interval. Combined with propafenone, which has proarrhythmic and conduction-slowing effects, the risk of ventricular arrhythmias including torsades de pointes may increase.
What this interaction means in plain words
Leuprolide and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Propafenone belongs to Cardiovascular.
Why it happens
Additive QT prolongation and effects on cardiac conduction.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes periodically during combined use. Reassess the antiarrhythmic if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Propafenone?
MediHelp rates the interaction as moderate. Leuprolide and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide may prolong the QT interval. Combined with propafenone, which has proarrhythmic and conduction-slowing effects, the risk of ventricular arrhythmias including torsades de pointes may increase.
How serious is the interaction between Leuprolide and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes periodically during combined use. Reassess the antiarrhythmic if QT prolongation develops.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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