Drug interactions
Leuprolide + Tetrabenazine
Severity: Moderate
Leuprolide and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes modest QT prolongation, and leuprolide may contribute further. The combination can increase arrhythmia risk, particularly with higher tetrabenazine doses.
What this interaction means in plain words
Leuprolide and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation from androgen deprivation (leuprolide) and tetrabenazine effects on cardiac repolarization.
What to do
Check a baseline ECG and monitor the QTc after starting the combination. Avoid it in patients with congenital long QT syndrome or a history of arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Leuprolide with Tetrabenazine?
MediHelp rates the interaction as moderate. Leuprolide and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes modest QT prolongation, and leuprolide may contribute further. The combination can increase arrhythmia risk, particularly with higher tetrabenazine doses.
How serious is the interaction between Leuprolide and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor the QTc after starting the combination. Avoid it in patients with congenital long QT syndrome or a history of arrhythmia.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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